Dr. Arterburn's Research: Dr. Arterburn, received the Ph.D in Chemistry from the University of Arizona, and was an American Cancer Society Postdoctoral Fellow at the Swiss Federal Institute of Technology and the University of Washington. He is currently Professor in the Department of Chemistry & Biochemistry NMSU, and PI of the NIH NCRR funded New Mexico IDeA Network for Biomedical Research, a statewide network that focuses on investigations of biomolecule structure and activity, cell signaling pathways, and pathogens. Dr. Arterburn is a member of the Women's Cancers program at the UNM Cancer Center, and co-leader with Dr. T. Oprea of the Chemistry sub-group of the UNM NIH Roadmap Molecular Libraries Screening Center. As an internationally known organic chemist, his research program involves the design and synthesis of receptor-targeted ligands and antiviral drugs, and participates in ongoing collaborative interdisciplinary research projects with investigators from the UNM College of Pharmacy, UNM School of Medicine, Los Alamos National Laboratory, U. Illinois, and the Southern Research Institute. His expertise includes synthesis of estradiol derivatives with fluorescent and radionuclide labels, nucleosides, carbohydrates, amino acids, substituted aromatic compounds and heterocycles. He has developed methodology for metal-mediated carbon-nitrogen and carbon-carbon bond forming reactions for the synthesis of novel probes and biologically active molecular scaffolds. His research program, described in 35 publications to date, has been supported by NIH NIGMS, NIAID, DOE, ACS-PRF, USAMRAA, and the USAMRC Breast Cancer Research Program.
Recent Publications: Synthesis of 17-alpha-estradiol-pyridin-2-yl hydrazine conjugates as effective ligands for labeling with Alberto's complex fac-[Re(OH2)3(CO)3]+ in water Jeffrey B. Arterburn, Cesear Corona, Kalla Venkateswara Rao, Kathryn E. Carlson, John A. Katzenellenbogen J. Org. Chem. 2003, 68, 7063-7070. Synthesis of (pyridin-2-yl)hydrazine conjugates as bifunctional chelates using the Suzuki/Miyaura reaction Jeffrey B. Arterburn, Bj K. Bryant, DaJun Chen Chemical Communications 2003, 1890-1891. A Convenient Method for the Oxidation of Alcohols with DMSO Catalyzed by Rhenium Catecholates Jeffrey B. Arterburn, Marc C. Perry, J. Jacob Strouse, and Michael D.Johnson Manuscript in preparation for submission to Advanced Synthesis & Catalysis, 2003. Polystyrene-Supported (Catecholato)oxorhenium Complexes: Catalysts for Alcohol Oxidation with DMSO and for Deoxygenation of Epoxides to Alkenes with Triphenylphosphine Jeffrey B. Arterburn, Minghua Liu and Marc C. Perry Helvetica Chimica Acta., 2002, 85, 3225-3236. Selective Oxidation of Secondary Alcohols Jeffrey B. Arterburn Tetrahedron 2001, 57, 9765-9788. Catalytic Reduction of Pertechnetate (99TcO4-) in Simulated Alkaline Nuclear Wastes Jonathan G. Bernard, Eve Bauer, Monique P. Richards, Jeffrey B. Arterburn, and Rebecca M. Chamberlin Radiochimica Acta 2001,89, 59-61. Catalytic Amination of 2-Substituted Pyridines with Hydrazine Derivatives Jeffrey B. Arterburn, Kalla Venkateswara Rao, Ranjit Ramdas, Benjamin R. Dible Organic Letters 2001, 3, 1351-1354. Catalytic Amination of 5-Iodouracil Derivatives Jeffrey B. Arterburn, Madhavi Pannala, Anicele M. Gonzalez, Tetrahedron Letters, 2001, 42, 1475-1477. Palladium Catalyzed Transfer Hydrogenation in Alkaline Aqueous Medium Jeffrey B. Arterburn, Madhavi Pannala, Anicele M. Gonzalez, Rebecca M. Chamberlin, Tetrahedron Letters, 2000, 41, 7847-7849. Functionalized Re(V) Organoimido Complexes as Potential Radiopharmaceuticals (II). Synthesis, Structural Characterization, and Reactivity of N-Succinimidyl Ester Derivatives with Amines. Jeffrey B. Arterburn, Kalla Venkateswara Rao, Donna M. Goreham, Marcela V. Valenzuela, Mylena S. Holguin, Keith A. Hall, Kevin C. Ott, and Jeffrey C. Bryan. Organometallics, 2000, 19, 1789-1795. Novel 17alpha-Ethynylestradiol Derivatives: Sonogashira Couplings Using Unprotected Phenylhydrazines. Jeffrey B. Arterburn, Kalla Venkateswara Rao, and Marc C. Perry, Tetrahedron Letters 2000, 41, 839-842. Solid- Supported Hydrazine Substrate for Labeling Estradiol Ligands with Rhenium. Jeffrey B. Arterburn, Kalla Venkateswara Rao, and Marc C. Perry, Angewandte Chemie 2000, 39, 771-772. Selective Rhenium-Catalyzed Oxidation of Secondary Alcohols With Methyl Sulfoxide in the Presence of Ethylene Glycol, A Convenient One-Pot Synthesis of Ketals Jeffrey B. Arterburn, and Marc C. Perry, Organic Letters 1999, 1, 769-771. Rhenium Catalyzed Oxidation of Thiols and Disulfides with Sulfoxides. Jeffrey B. Arterburn, Marc C. Perry, Sherry L. Nelson, Mylena S. Holguin, Benjamin R. Dible, J. Am. Chem Soc. 1997, 119 , 9309-9310. Rhenium Catalyzed Sulfurization of Phosphorus(III) Compounds with Thiiranes: New Reagents for Phosphorothioate Ester Synthesis. Jeffrey B. Arterburn, Marc C. Perry, Tetrahedron Letters 1997, 38, 7701-7704. Functionalized Re(V) Organoimido Complexes as Potential Radiopharmaceuticals. Syntheses of Glycine Derivatives and the Structure Determination of a Rhenium Analogue of Chlorambucil. Jeffrey B. Arterburn, Ian M. Fogarty, Keith A. Hall, Kevin C. Ott, Jeffrey C. Bryan, Angew. Chem. Int. Ed. Engl. 1996, 35, 2877-2879. Rhenium Catalyzed Oxidation of Sulfides with Phenyl Sulfoxide. Jeffrey B. Arterburn, Sherry L. Nelson, J. Org. Chem., 1996, 61, 2260-2261. Recent Presentations: Synthesis of biotin derivatives for metal catalyzed carbon-carbon coupling reactions Jeffrey B. Arterburn, Cesear Corona, BJ Bryant Abstracts of Papers of the American Chemical Society, V.223(pt.2)pp.B219-B219 Apr.7, 2002. Synthesis of 2-hydrazinopyridyl-17a-estradiol derivatives; Effective ligands for the coordination of tricarbonylrhenium(I). Jeffrey B. Arterburn, Kalla Venkateswara Rao, Cesear Corona, Kathryn Carlson, John Katzenellenbogen Abstracts of Papers of the American Chemical Society, V.223(pt.2)pp.B221-B221 Apr.7, 2002.
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