Research projects in Dr. Arterburn's laboratory have originated from an interest in developing new methodology for organic synthesis, an appreciation for the unique chemistry of transition metal complexes containing metal-ligand multiple bonds, and a desire to synthesize new antiviral drugs and radiopharmaceuticals.

We have recently shown that rhenium oxo complexes catalyze oxygen atom transfer reactions from sulfoxide donors, providing a very mild method for oxidizing organic compounds. Specific examples include a method for the selective oxidation of secondary alcohols that directly provide ketals, polymer-supported alcohol oxidation catalysts, and a catalytic method for the synthesis of nucleotide phosphorothioate esters from thiiranes.

We are also using catalytic carbon-nitrogen bond forming reactions (amination) to synthesize novel heterocyclic amines. Specific examples include the copper catalyzed synthesis of 5-aminouracil derivatives, and the palladium-catalyzed synthesis of pyridyl hydrazines. We have recently initated a program for the combinatorial synthesis of new antivirals targeted against Hantavirus, as part of an effort to establish a Center for Emerging Pathogen Research at New Mexico State University. Antiviral candidates are screened through an active collaboration with Dr. C. Jonsson.

The group is actively involved in the synthesis of novel pyridyl hydrazine derivatives of estradiol as radiopharmaceuticals for the selective imaging and detection of breast cancer. We have recently shown that the multiple-bonded imido linkage can be used to connect the metal center with highly functionalized organic ligands. We are currently developing new methods for radiolabeling various other organic receptor ligands (e.g. peptide, steroid, nucleotide) for selective imaging and radiotherapy.