Chemistry
Home
Faculty
Admissions
Courses
Research
Facilities
Links
Contact
Us
Search
NMSU
Home |
 WILLIAM
A. MAIO
Assistant
Professor
B.S.
Fordham University, Bronx, NY 2003
Ph.D.
Johns Hopkins University, Baltimore, MD 2008
Postdoctoral, University of Pennsylvania
(575)-646-4017
RESEARCH PUBLICATIONS RESEARCH
LINKS
Research
Interests
My
research program will focus on the exploration of new chemical space
with interests at the interface between chemistry and biology.
Through diversity-oriented synthesis, one of our goals is to engineer
potential chemotherapeutics and small-molecule inhibitors, with a focus
on designing compound libraries inspired by nature.
My main research interest entails the development of new synthetic
methods with application to short, efficient natural and natural product-like
total syntheses. Secondary metabolites, of marine origin, which possess
interesting molecular architecture as well as promising biological
activity will be our primary targets.
RECENT
PUBLICATIONS:
-
William Anthony Maio
"Inventing New Synthetic Ring Enlargement Methods and Exploring
the Use of Novel Trioxanes for the Treatment of Malaria."
The Johns Hopkins University, 2009, 176 pp., Advisor: Gary H.
Posner
-
Posner,
G.H.; Maio, W.A.; Kalinda, A.S.
“Electronically Stabilized Versions of the Antimalarial Acetal
Trioxanes Artemether and Artesunate.”
Biorg. Med. Chem. 2008, 16, 5247.
Posner, G.H.; Chang, W.; Hess, L.; Woodard, L.; Sinishtaj, S.;
Usera, A.; Maio, W.A.; Rosenthal, A.S.; Kalinda,
A.S.; D’Angelo, J.G.; Petersen, K.; Stohler, R.; Chollet, J.; Santo-Thomas,
J.; Snyder, C.; Rottman, M.; Wittlin, S.; Brun, R.; Shapiro, T.
“Malaria-infected Mice are cured by Oral Administration of New
Artemisinin Derivatives.”
J. Med. Chem. 2008, 51, 1035.
Maio, W.A.; Posner, G.H.
“Cyclopentanone Ring Expansion Leading to Functionalized delta-Lactams:
Short Synthesis of Simple Sedum Alkaloids.”
Org. Lett. 2007, 9, 2673.
Posner, G.H.; Hatcher, M.A.; Maio, W.A.
“New Silicon-Mediated, Sequential Ring Expansions of n-sized 2-Cycloalkenones
into Hydroxyolefinic n+m+p Medium-Sized Lactones: Short Synthesis
of (-)-Phoracantholide-J.”
Org. Lett. 2005, 7, 4301.
Ciaccio, J.A.; Smrtka, M.; Maio, W.A.; Rucando,
D.
“Synthesis of b-Hydroxy Nitriles and 1,3-Amino Alcohols from Epoxides
Using Acetone Cyanohydrin as a LiCN Precursor.”
Tetrahedron Lett. 2004, 45, 7201.
|
