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SHELLEY L. LUSETTI
Assistant Professor
A.A. Sacramento City
College (1994)
B.S. University of
California, Santa Barbara (1998)
Ph.D. University of
Wisconsin, Madison (2002)
Postdoctoral, University
of Wisconsin, Madison (2002-2004)
slusetti@nmsu.edu
(505) 646-6016
RESEARCH
PUBLICATIONS
The cellular genome
maintenance processes of DNA replication, recombination, and repair
are highly interconnected, sharing multiple pathways and common
enzymes. For example, the major pathway for repair of common, but
potentially lethal, chromosomal double-stranded DNA breaks (DSBs) is
homologous recombination. While integration of replication, repair,
and recombination pathways offers an elegant means of regulating
cellular DNA metabolism, it also presents an Achilles heel:
mutations that inactivate components of recombinational DNA repair
pathways lead to gross chromosomal instability that can cause birth
defects, cancer, and premature aging. A physical understanding of
the function of key enzymes that link genome maintenance processes
is thus critical both for elucidating the basic DNA metabolic
strategies of cells and for understanding the etiology of several
crippling diseases. The broad interest of the lab is to define the
cellular processes underlying chromosomal maintenance by studying
the enzymes and regulatory mechanisms that control it using
biochemical methods.
RECENT PUBLICATIONS:
Lusetti, S.L., Hobbs, M.D., Stohl, E.A.,
Chitteni-Pattu, S., Inman, R.B., Seifert, H.S., and Cox, M.M. (2006)
The RecF protein antagonizes RecX function via direct
interaction. Molecular Cell, 21, 41-50.
Lusetti, S.L., Drees, J.C., Stohl, E.A., Seifert, H.S.,
and Cox, M.M. (2004) The DinI and RecX proteins are competing
modulators of RecA function. J. Biol. Chem., 279,
55073-9.
Drees, J.C., Lusetti, S.L., Chitteni-Pattu, S.,
Inman, R.B., and Cox, M.M. (2004) A RecA filament capping mechanism
for RecX protein. Molecular Cell, 15, 789-98.
Drees,
J.C., Lusetti, S.L. and Cox, M.M. (2004) Inhibition of RecA protein
by the Escherichia coli RecX protein: Modulation by the RecA
C terminus and filament functional state. J. Biol. Chem.,
279, 52991-7
Lusetti, S.L., Voloshin, O.N., Inman, R.B., Camerini-Otero,
R.D., and Cox, M.M., (2004) The DinI protein stabilizes RecA protein
filaments. J. Biol. Chem., 279, 30037-46
Lusetti,
S.L., Wood, E.A., Fleming, C.D., Modica, M.J., Korth, J.,
Abbott, L., Dwyer, D.W., Roca, A.I., Inman, R.B. and Cox, M.M.
(2003) C-terminal deletions of the E. coli RecA protein:
Characterization of in vivo and in vitro effects.
J. Biol. Chem., 278, 16972-80
Lusetti,
S.L., Shaw, J.J. and Cox, M.M. (2003) Magnesium ion-dependent
activation of the RecA protein involves the C terminus. J. Biol.
Chem., 278, 16981-88
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