NMSU - Department of Chemisty and Biochemistry

ROBERT V. HOFFMAN

A.B. (Case Western Reserve) 1966;
Ph.D. (Case Western Reserve) 1970;
Postdoctoral (Ohio State) 1970

Dr. Hoffman's research interests lie in the areas of synthesis and synthetic methodology. His group has developed methods by which arenesulfonyloxy leaving groups can be attached oxidatively to organic compounds, particularly 2-sulfonyloxy esters and ketones, and N-sulfonyloxy amides. The unique chemistry found for these compounds has resulted in new strategies for the synthesis of a variety of natural and unnatural products, drug candidates, protease inhibitors, peptide mimetics, and DNA cleaving reagents. Recently a new program in combinatorial chemistry targeted towards ß-turn mimics has been started.

SELECTED PUBLICATIONS:

Origins of Regioselectivity in the Reactions of a-Lactams with Nucleophiles. Two Distinct Acid-Catalyzed Pathways Involving N- and O-Protonation
Hoffman, R. V.; Zhao, Z.; Costales, A.; Clarke, D.,
J. Org. Chem., 2002, 67, 5284.
Synthesis of 2-Oxazolone-4-Carboxylates from 3-Nosyloxy- and 3-Bromo-2-ketoesters
Okonya, J. F.; Hoffman, R. V.; Johnson, M.C.,
J. Org. Chem., 2002, 67, 1102.
Highly Stereoselective Synthesis of syn- and anti-N-Protected-1,2-Aminoalcohols
Hoffman, R. V.; Maslouh, N.,
J. Org. Chem., 2002, 67, 1045.
Highly Stereoselective Synthesis of anti-N-Protected-a-Amino Epoxides
Hoffman, R. V.; Weiner, W. S.; Maslouh, N.,
J. Org. Chem., 2001, 66, 5790-95.
Comments and Commentary
Hoffman, R. V.,
Chemtracts, 2001, 14, 805.
Comments and Commentary
Hoffman, R. V.,
Chemtracts, 2001, 14, 500-504.