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ARAVAMUDAN S. GOPALAN

Professor

B.S., M.S. (Madras) 1973, 1975;
Ph.D. (Ohio State) 1980;
Postdoctoral (Stanford) 1980 and (Wisconsin) 1982

agopalan@nmsu.edu
(505)-646-2589

 

 

RESEARCH          PUBLICATIONS          GROUP WEBPAGE

 

Chelators for Environmental Applications

• Remediation of transuranic waste (Plutonium processing)
• Water soluble chelators for soil washing and decontamination
• Selective extractants for actinides-Calixarenes
• Polymeric chelators for radioactive waste stream remediation using ultrafiltration
• Selective separation of cesium and strontium from spent nuclear fuel rods
• Chelators for use in supercritical carbon dioxide (Argonne National Lab collaboration)

 

Chelators for Biomedical Applications

• Develop chelators for in-vivo removal of excess Fe3+ for treatment of Cooley's anemia (therapeutic applications)
• Understand the mechanism for siderophore mediated transport of Fe3+ across the cell membrane in bacteria and other systems
• Development of diagnostic agents such as contrast agents for magnetic resonance imaging

                      

Ligand Development

• Develop convenient methodology for the preparation of useful metal ion binding systems
• Develop practical tethering technology for attachment of ligands to useful platforms
• Develop new ligand systems for metal ion binding                                             

 

 

        

 

 

 

               

 

Synthetic Methodology-Sulfones

• Methods to prepare chiral amino and hydroxysulfones
• Investigation of novel cyclization chemistry to prepare heterocycles
• Applications to the synthesis of biologically interesting targets


RECENT PUBLICATIONS:

  • Synthetic Methodology for the Preparation of N-hydroxysulfamides
    Devanathan, K.; Bell, J.A.; Wilkins, P.C.; Jacobs, H.K.; Gopalan, A.S.
    Tetrahedron Lett. 2007, 48, 8029-8033
  • New Methodology for the Preparation of 3-hydroxy-2-pyridinone (3,2-HOPO) Chelators 2. Reactions of Alcohols, Phenols and Thiols with a Novel Electrophilic 3,2-HOPO Precursor
    Chittamuru, S.; Lambert, T.N.; Martinez, G.; Jacobs, H.K.; Gopalan, A.S.
    Tetrahedron Lett. 2007, 48, 567-571
  • Selective Fluorescence Detection of Divlant and Trivalent Metal Ions with Functionalized Lipid Membranes
    Pincus, J.L.; Jin, C.; Huang, W.; Jacobs, H.K.; Gopalan, A.S.; Song, Y.; Shelnutt, J.A.; Sasaki, D.Y.
    J. Mater. Chem., 2005, 15, 2938-45
  • Mechanistic variations in the oxidation of Piloty's acid by metal complexes
    Wilkins, P. C.; Jacobs, H. K.; Johnson, M. D.; Gopalan, A. S.
    Inorganic Chemistry, 2004, 43, 7877-7881
  • Synthesis of ether-linked fluorocarbon surfactants and their aggregational properties in organic solvents
    Huang, W.; Jin, C.; Derzon, D. K.; Huber, T. A.; Last, J. A.; Provencio, P. P.; Gopalan, A. S.; Dugger, M.; Sasaki, D. Y.
    Journal of Colloids and Interface Science, 2004, 272, 457-464.
  • Synthesis of symmetrical methylenebis(alkyl hydrogen phosphonates) by selective cleavage of methylenebis(dialkyl phosphonates) with morpholine
    Gantla, V. R.; Jacobs, H.; Gopalan, A. S.; Barrans Jr., R. E.; Dietz, M. L.; Stepinski, D.; Herlinger, A. W.
    Synthetic Communications, 2004, 34(2), 331-344.
  • Supercritical Carbon Dioxide-Separations and Processes
    Gopalan, A.S.; Wai, C. M.; Jacobs, H.K., Eds.
    ACS Symposium Series (Volume 860), American Chemical Society, Washington, DC; 2003.
  • “An Introduction to Separations and Processes Using Supercritical Carbon Dioxide” in Supercritical Carbon Dioxide-Separations and Processes"
    Gopalan, A.S.; Wai, C. M.; Jacobs, H.K., Eds.
    ACS Symposium Series (Volume 860), American Chemical Society, Washington, DC; 2003, pp. 2–8.
  • Synthesis of lactams and other nitrogen heterocycles by intramolecular cyclizations of carbamates and acyl derivatives of aminosulfones
    Hernandez, N.M.; Sedano, M.J.; Jacobs, H.K.; Gopalan*, A.S.,
    Tetrahedron Letters, 2003, 44, 4035-4039.
  • Synthesis and metal ion complexation properties of a novel polyethyleneimine N-methylhydroxamic acid water soluble polymer
    Bisset, W.; Jacobs, H.K.; Koshti, N.; Stark, P.; Gopalan*, A.S.,
    Reactive and Functional Polymers, 2003, 55, 109-119.
  • Convenient synthetic methods for the preparation of N-fluoroalkylhydroxamic acids
    Koshti, N.; Gantla, V. R.; Jacobs, H.K, Gopalan, A.S.,
    Synthetic Commun., 2002, 32/24, 3779-3790.
  • New methodology for the preparation of 3-hydroxy-2-pyridinone (3,2-HOPO) chelators - Reaction of amines with a novel electrophilic 3,2-HOPO precursor
    Lambert, T. N.; Chittamuru, S.; Jacobs, H. K.; Gopalan, A. S., Jin, C.,
    Tetrahedron Letters, 2002, 43/41, 7379-7383.
  • Intramolecular cyclization reactions of carbonyl derivatives of hydroxysulfone
    Jacobs, H.; Cervantes-Lee, F.; Gopalan, A.S,
    Tetrahedron, 2002, 58/19, 3737-3746.
  • Chiral non-racemic dihydroxysulfones via hydrolytic kinetic resolutions-synthesis of oxacyclic ring systems using intramolecular acylation strategies
    Jin, C.Y.; Ramirez, R.D.; Gopalan, A.S.
    Tetrahedron Lett., 2001, 4747-4750.
  • New Intramolecular alkylation and Michael addition reactions of hydroxysulfone derivatives- Stereoselective preparation of functionalized cyclic ethers
    Jin, C.; Jacobs, H.; Gopalan, A.S.,
    Tetrahedron Lett., 2000, 41/50, 9753-9757.
  • Metal Ion Complexation and Extraction Behavior of Some Acyclic Analogs of tert-Butyl-Calix[4]arene Hydroxamate Extractants in Calixarenes for Separations
    Lambert, T. N.; Tallant, M. D.; Jarvinen, G. D.; Gopalan, A. S.,
    ACS Symposium Series (Volume 757), American Chemical Society, Washington, DC; 2000, pp 208-222.
    Lumetta G., Rogers, R. and Gopalan, A.