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Assistant Professor
B. A., Chemistry, Carleton College, 1999 Ph. D., Chemistry, University of California San Diego, 2004 Postdoc, University of Montreal, 2004-2006
delvalle@nmsu.edu fax: (575) 646-6004 Office: CB 218
RESEARCH PUBLICATIONS GROUP WEBSITE COURSES
We are an organic chemistry laboratory interested in the synthesis of structurally complex peptidomimetics and natural products with direct relevance to cancer biology and infectious diseases. We utilize various constrained cyclic architectures in our studies on the bioactive conformations of peptides, and in the development of drug leads through structure-based design. For more detailed information on current projects please visit the research page of our group website by clicking here.
"b-Substituted-D-Leucines and their Relevance in the Total Synthesis of Natural and Non-Natural Aeruginosins" (Book Chapter) Del Valle, Juan R.; Wang, X.; Ersmark, K.; Hanessian, S., in Current Frontiers in Asymmetric Synthesis and Application of alpha-Amino Acids, 2008, ACS Symposium Series, in press. "Chemistry and Biology of the Aeruginosin Family of Serine Protease Inhibitors" (Review), Ersmark, K.; Del Valle, J. R.; Hanessian, S. Angew. Chem. Int. Ed. 2008, 47, 1202. "Structure-based Organic Synthesis of Unnatural Aeruginosin Hybrids as Potent Inhibitors of Thrombin", Hanessian, S.; Ersmark, K.; Wang, X.; Del Valle, J. R.; Blomberg, N.; Xue, Y.; Fjellstrom, O. Bioorg. Med. Chem. Lett. 2007, 17, 3480. "Total Synthesis and Structural Confirmation of Chlorodysinosin A", Hanessian, S.; Del Valle, J. R.; Xue, Y.; Blomberg, N. J. Am. Chem. Soc. 2006, 128, 10491. "Synthetic Studies in the Intramolecular Carbocyclization of N-Acyloxyiminium Ions. Stereoelectronic and Steric Implications of Nucleophilic Alkene, Alkyne, and Allene Tethers", Hanessian, S.; Tremblay, M.; Marzi, M.; Del Valle, J. R. J. Org. Chem. 2005, 70, 5070. “Utilizing the Intramolecular Fukuyama–Mitsunobu Reaction for a Flexible Synthesis of Novel Heterocyclic Scaffolds for Peptidomimetic Drug Design”, Zapf, C. W.; Del Valle, J. R.; Goodman, M. Bioorg. Med. Chem. Lett. 2005, 15, 4033. “An Efficient RCM-Based Synthesis of Orthogonally Protected meso-DAP and FK565”, Del Valle, J. R.; Goodman, M. J. Org. Chem. 2004, 69, 8946. “Asymmetric Hydrogenations for the Synthesis of Boc-Protected 4-Alkylprolinols and Prolines”, Del Valle, J. R.; Goodman, M. J. Org. Chem. 2003, 68, 3923. “Stereoselective Synthesis of Boc-Protected cis and trans-4-Trifluoromethylprolines by Asymmetric Hydrogenation Reactions”, Del Valle, J. R.; Goodman, M. Angew. Chem. Int. Ed. 2002, 41, 1600. “Molecular Basis of Sweet Taste in Dipeptide Taste Ligands”, Goodman, M.; Del Valle, J. R.; Amino, Y.; Benedetti, E. Pure Appl. Chem. 2002, 74, 1109.
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JUAN
R. DEL VALLE