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Jeff ArterburnJEFFREY B. ARTERBURN

Professor

B.A. (summa cum laude) University of Colorado, Denver, CO 1986
Ph.D., University of Arizona, AZ 1990
Postdoctoral, ETH-Zurich 1991
Postdoctoral, University of Washington, WA 1991-1992

Chemistry & Biochemistry
New Mexico State University
PO Box 30001
MSC 3C
Las Cruces, NM 88003-8001
jarterbu@nmsu.edu
(575) 646-2738

 

RESEARCH      PUBLICATIONS   

Research projects in Dr. Arterburn's laboratory have originated from an interest in developing new methodology for organic synthesis, an appreciation for the unique chemistry of transition metal complexes containing metal-ligand multiple bonds, and a desire to synthesize new antiviral drugs and radiopharmaceuticals.

We have recently shown that rhenium oxo complexes catalyze oxygen atom transfer reactions from sulfoxide donors, providing a very mild method for oxidizing organic compounds. Specific examples include a method for the selective oxidation of secondary alcohols that directly provide ketals, polymer-supported alcohol oxidation catalysts, and a catalytic method for the synthesis of nucleotide phosphorothioate esters from thiiranes.

We are also using catalytic carbon-nitrogen bond forming reactions (amination) to synthesize novel heterocyclic amines. Specific examples include the copper catalyzed synthesis of 5-aminouracil derivatives, and the palladium-catalyzed synthesis of pyridyl hydrazines. We have recently initated a program for the combinatorial synthesis of new antivirals targeted against Hantavirus, as part of an effort to establish a Center for Emerging Pathogen Research at New Mexico State University. Antiviral candidates are screened through an active collaboration with Dr. C. Jonsson.

The group is actively involved in the synthesis of novel pyridyl hydrazine derivatives of estradiol as radiopharmaceuticals for the selective imaging and detection of breast cancer. We have recently shown that the multiple-bonded imido linkage can be used to connect the metal center with highly functionalized organic ligands. We are currently developing new methods for radiolabeling various other organic receptor ligands (e.g. peptide, steroid, nucleotide) for selective imaging and radiotherapy.

 

SELECTED PUBLICATIONS:

 

  • Synthesis and anti-Hantaan virus activity of N1-3-fluorophenyl-inosine. Chung DH, Strouse JJ, Sun Y, Arterburn JB, Parker WB, Jonsson CB. Antiviral Research 2009, 80-85; DOI 10.1016/j.antiviral.2009.03.007. PMCID: In Process
  • In vivo effects of a GPR30 antagonist. Dennis MK, Burai R, Ramesh C, Petrie WK, Alcon SN, Nayak TK, Bologa CG, Leitao A, Brailoiu E, Deliu E, Dun NJ, Sklar LA, Hathaway HJ, Arterburn JB, Oprea TI, Prossnitz ER. Nature Chemical Biology 5, 3 May 2009, 421-427; DOI 10.1038/nchembio.168. PMCID: In Process
  • Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes. Young SM, Bologa CM, Fara D, Bryant BK, Strouse JJ, Arterburn JB, Ye RD, Oprea TI, Prossnitz ER, Sklar LA, Edwards BS. Cytometry A. 2009; 75A (3): 253-263. PMCID: 2645486
  • Expression of estrogen receptor GPR30 in the rat spinal cord, autonomic and sensory ganglia. Dun SL, Brailoiu GC, Gao X, Brailoiu E, Arterburn JB, Prossnitz ER, Oprea TI, Dun NJ. Journal of Neuroscience Research 2009; 87: 1610-1619. PMCID: PMC2692324
  • Prossnitz ER, Oprea TI, Sklar LA, Arterburn JB. The ins and outs of GPR30: A transmembrane estrogen receptor. Journal of Steroid Biochemistry & Molecular Biology 2008; 109 (3): 350-353. PMCID: 5481563
  • Nayak TK, Hathaway HH, Ramesh C, Arterburn JB, Dai D, Sklar LA, Norenberg JP and Prossnitz ER. Pre-clinical development of a neutral, estrogen receptor-targeted tridentate 99mTc(I) estradiol pyridine-2-yl hydrazine derivative for imaging of breast and endometrial cancers. J Nucl Med 2008 June; 49(6):978-986. PMCID: 2435083
  • Bisphenol A directly targets tubulin to disrupt spindle organization in embryonic and somatic cells. George O, Bryant BK, Ramesh C, Corona C, Arterburn JB and Shuster CB. ACS Chem Biol 2008; (3):167-179.
  • Synthesis of 1-ß-D-ribofuranosyl-3-ethynyl-[1,2,4] triazole and its In Vitro and In Vivo efficacy against hantaviruses. Chung DH, Kumarapperuma SC, Sun Y, Li Q, Chu Y-K, Arterburn JB, Parker WB, Smith J, Spik K, Ramanathan H, Schmaljohn CS and Jonsson CB. Antiviral Research 2008; (79):19-27.
  • Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Prossnitz ER, Arterburn JB, Smith HO, Oprea TI, Sklar LA, and Hathaway HJ. Ann Rev Physiol 2008; (70):165-190.
  • GPR30: a novel therapeutic target in estrogen- related disease. Prossnitz ER, Sklar LA, Oprea TI and Arterburn JB. Trends in Pharmaceutical Science 2008; 29(3):116-123.
  • Ribavirin Reveals a Lethal Threshold of Allowable Mutation Frequency. Dong-Hoon Chung, Yanjie Sun, William Parker, Jeffrey Arterburn, Al Bartolucci, and Colleen B. Jonsson, (2007). J.Virology, in press.
  • Synthetic Estrogen Ligands Demonstrate the Functionality of Intracellular GPR30. Chetana M. Revankar, Hugh Mitchell, Ritwik Burai, Cesear Corona, Chinnasamy Ramesh, Larry A. Sklar, Jeffrey Arterburn, and Eric R. Prossnitz, ACS Chemical Biology 2007, ASAP Article; DOI: 10.1021/cb700072n.
  • Structural effects on the phosphorylation of 3-substituted 1-β-D-ribofuranosyl-1,2,4-triazoles by human adenosine kinase. Sidath C. Kumarapperuma, Yanjie Sun, Marjan Jeselnik, Kiwon Chung, William B. Parker, Colleen B. Jonsson, Jeffrey B. Arterburn (2007). Bioorg. Med. Chem. Lett. 17, 3203-3207.
  • GPR30: A G protein-coupled receptor for estrogen. Eric R. Prossnitz, Jeffrey B. Arterburn, Larry A. Sklar, (2007). Molecular and Cellular Endocrinology 265-266, 138-142.
  • GPR30: a novel intracellular estrogen receptor. Chetana M. Revankar, Larry A. Sklar, Jeffrey B. Arterburn, and Eric R. Prossnitz., Trends in Endocrinology and Metabolism (2006) in press.
  • Characterization of a radiolabeled small molecule targeting LFA-1 expression in lymphoma and leukemia. Rahul B. Poria, Jeffrey P. Norenberg, Tamara L. Anderson, Carston R. Wagner, Jeffrey B. Arterburn, Richard S. Larson (2006). Cancer Biotherapy and Radiopharmaceuticals, 21, No 5, 418-426.
  • Linkage Effects on Binding Affinity and Activation of GPR30 and Estrogen Receptors ERα/β with Tridentate Pyridin-2-yl Hydrazine Tricarbonyl-Re/99mTc(I) Chelates. Chinasamy Ramesh, Bj, K. Bryant, Tapan Nayak, Chetana M. Revankar, Tamara Anderson, Jeffrey P. Norenberg, Kathryn E. Carlson, John A. Katzenellenbogen, Larry A. Sklar, Eric R. Prossnitz, Jeffrey B. Arterburn. J. Am. Chem. Soc. 128, 14476-14477.
  • Steroid-binding GPCRs: New Drug Discovery Targets for Old Ligands? Eric R. Prossnitz, Jeffrey b. Arterburn, Bruce S. Edwards, Larry A. Sklar, Tudor I. Oprea (2006). Expert Opinion in Drug Discovery 1(2)137-150.
  • Synthesis of a biotin-derived alkyne for Pd-catalyzed coupling reactions. Cesear Corona, Bj K. Bryant, Jeffrey B. Arterburn. Org. Letters 2006. 8, 1883-1886.
  • Virtual and Biomolecular Screening Converge on a Selective Agonist for GPR30. Cristian G. Bologa, Chetana M. Revankar, Susan M. Young, Bruce S. Edwards, Jeffrey B. Arterburn, Matthew A. Parker, Sergey E. Tkachenko, Nikolay P. Savchuck, Larry A. Sklar, Tudor I. Oprea* and Eric R. Prossnitz. Nature Chemical Biology  (2006). 2, 207-212.
  • Applications of boronic acids in selective C-C and C-N arylation of purines. J. Jacob Strouse, Marjan Jeselnik, Jeffrey B. Arterburn. Acta Chim. Slov. (2005) 52, 187-199.
  • Copper catalyzed arylation with boronic acids for the synthesis of N1-aryl purine nucleosides. J. Jacob Strouse, Marjan Jeselnik, Fredrick Tapaha, Colleen B. Jonsson, Jeffrey B. Arterburn. Tetrahedron Letters (2005) 46, 5699-5702.
  • Potential Importance of Error Catastrophe to the Development of Antiviral Strategies for Hantaviruses. Colleen B. Jonsson, Brook G. Milligan, and Jeffrey B. Arterburn. Virus Research 2005, 307, 195-205.
  • A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling.
    Chetana M. Revankar, Daniel F. Cimino, Larry A. Sklar, Jeffrey B. Arterburn, Eric R. Prossnitz. Science  (2005) 307, 1625-1630.
  • Synthesis of (pyridin-2-yl)hydrazine conjugates as bifunctional chelates using the Suzuki/Miyaura reaction. Jeffrey B. Arterburn, Bj K. Bryant, DaJun Chen. Chemical Communications (2003) 1890-1891.
  • Synthesis of 17-alpha-estradiol-pyridin-2-yl hydrazine conjugates as effective ligands for labeling with Alberto's complex fac-[Re(OH2)3(CO)3]+ in water.
    Jeffrey B. Arterburn, Cesear Corona, Kalla Venkateswara Rao, Kathryn E. Carlson, John A. Katzenellenbogen. J. Org. Chem. (2003) 68, 7063-7070.
  • Polystyrene-Supported (Catecholato)oxorhenium Complexes: Catalysts for Alcohol Oxidation with DMSO and for Deoxygenation of Epoxides to Alkenes with Triphenylphosphine.
    Jeffrey B. Arterburn, Minghua Liu and Marc C. Perry. Helvetica Chimica Acta., (2002) 85, 3225-3236.
  • Selective Oxidation of Secondary Alcohols. Jeffrey B. Arterburn. Tetrahedron  (2001), 57, 9765-9788.
  • Catalytic Amination of 2-Substituted Pyridines with Hydrazine Derivatives. Jeffrey B. Arterburn, Kalla Venkateswara Rao, Ranjit Ramdas, Benjamin R. Dible
    Organic Letters (2001), 3, 1351-1354.
  • Catalytic Amination of 5-Iodouracil Derivatives. Jeffrey B. Arterburn, Madhavi Pannala, Anicele M. Gonzalez. Tetrahedron Letters (2001), 42, 1475-1477.
  • Catalytic Reduction of Pertechnetate (99TcO4-) in Simulated Alkaline Nuclear Wastes.
    Jonathan G. Bernard, Eve Bauer, Monique P. Richards, Jeffrey B. Arterburn, and Rebecca M. Chamberlin. Radiochimica Acta (2001), 89, 59-61.
  • Palladium Catalyzed Transfer Hydrogenation in Alkaline Aqueous Medium. Jeffrey B. Arterburn, Madhavi Pannala, Anicele M. Gonzalez, Rebecca M. Chamberlin. Tetrahedron Letters (2000), 41, 7847-7849.
  • Functionalized Re(V) Organoimido Complexes as Potential Radiopharmaceuticals (II). Synthesis, Structural Characterization, and Reactivity of N-Succinimidyl Ester Derivatives with Amines. Jeffrey B. Arterburn, Kalla Venkateswara Rao, Donna M. Goreham, Marcela V. Valenzuela, Mylena S. Holguin, Keith A. Hall, Kevin C. Ott, and Jeffrey C. Bryan. Organometallics (2000), 19, 1789-1795.
  • Novel 17α-Ethynylestradiol Derivatives: Sonogashira Couplings Using Unprotected Phenylhydrazines. Jeffrey B. Arterburn, Kalla Venkateswara Rao, and Marc C. Perry. Tetrahedron Letters (2000), 41, 839-842.
  • Solid- Supported Hydrazine Substrate for Labeling Estradiol Ligands with Rhenium. Jeffrey B. Arterburn, Kalla Venkateswara Rao, and Marc C. Perry, Angewandte Chemie (2000), 39, 771-772.
  • Solid- Supported Hydrazine Substrate for Labeling Estradiol Ligands with Rhenium. Jeffrey B. Arterburn, Kalla Venkateswara Rao, and Marc C. Perry, Angewandte Chemie (2000), 39, 771-772.
  • Trichlorooxo(triphenylphosphine)(triphenylphosphine oxide)rhenium(V). Jeffrey C. Bryan, Marc C. Perry, and Jeffrey B. Arterburn. Acta Crystallogr. (C) (1998), 54, 1607-1608.